College of Engineering, Design & Computing Events

5 Feb | Notice of Special Interest (NOSI): Development of Organotypic Culture Models for Transplantation Immunology Research

NIH

This Notice of Special Interest (NOSI) encourages applications that focus on the development and validation of tissue-, stem-, or progenitor-cell-derived “3D” organotypic culture models (OCM) for transplantation immunology research. This NOSI will support applications that focus on development of allogeneic or xenogeneic OCM to study immunologic features of transplant-related diseases or conditions, including:

• Cellular rejection, antibody-mediated rejection, or mixed cellular and antibody-mediated rejection
• Sensitization, i.e., immunogenicity of pre-existing allo-reactive or xeno-reactive antibodies
• Tolerance and/or accommodation, i.e., resistance of an organ to immune-mediated damage
• Zoonotic infection in the context of immunosuppression and exposure to a xenograft
• Graft-versus-host disease
• Transplant related ischemia reperfusion injury