Encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $750,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, X-ray diffractometers, high throughput robotic screening systems, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers. Applicant organizations may submit more than one application, provided that each application is scientifically distinct. Please work with your research administrator and OGC to ensure no requests are duplicated.