Through this Dear Colleague Letter (DCL), NSF encourages proposals to the Cyberinfrastructure for Emerging Science and Engineering Research (CESER) program2 within the Office of Advanced Cyberinfrastructure for pilot projects that bring together researchers and cyberinfrastructure (CI) experts to develop the means of combining existing community data resources and shared data-focused CI into new integrative and highly performing data-intensive discovery workflows that empower new scientific pathways.