Future computing systems with ultra-low energy storage can be built on principles derived from organic systems that are at the intersection of biology, physics, chemistry, materials science, computer science and engineering. Next-generation information storage technologies can be envisioned that are driven by biological principles with use of biomaterials in the fabrication of devices and systems that can store data for more than 100 years with storage capacity 1,000 times more than current storage technologies. Such a research effort can have a significant impact on the future of information storage technologies. This focused solicitation seeks high-risk/high- return interdisciplinary research on novel concepts and enabling technologies that will address the fundamental scientific issues and technological challenges associated with the underpinnings of synthetic biology integrated with semiconductor technology. This research will foster interactions among various disciplines including biology, physics, chemistry, materials science, computer science and engineering that will enable in heretofore-unanticipated breakthroughs.