Publications

Research Publications 2012-current

  • Joshua R. St Clair, David Ramirez, Samantha Passman, Richard K.P. Benninger. "Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models". Nature Communication. [2018]; 9(1): 1742. PMID: 29717116​
  • Richard K.P Benninger, David J. Hodson. "New Understanding of b-cell ​​​​​Heterogeneity and In Situ Islet Function". Diabetes. [2018]; 67(4): 537-547. PMID: 29559510
  • Matthew J. Westacott, Nurin W.F. Ludin, Richard K.P. Benninger. "Spatially Organized b-cell subpopulations control electrical dynamics across islets of Langerhans". Biophysical Journal. [2017];​ PMID: 28877492​
  • Matthew J. Westacott, Nikki L. Farnsworth,​ Joshua R. St Clair, Greg Poffenberger, Audrey Heintz, Nurin W. Ludin, Nathaniel J. Hart, Alvin C. Powers, Richard K.P. Benninger. "Age-dependent decline in coordinated [Ca2+] and insulin secretory dynamics in human pancreatic islets". Diabetes. [2017 Sep]; 66(9): 2436-2445. PMID: 2858809
  • Aleena M. Notary, Matthew J. Westacott, Thomas H. Hraha, Marina Pozzoli, Richard K.P. Benninger. ''Decrease in gap junction modulation recovers [Ca2+] and insulin secretion in Neonatal Diabetes Mellitus dependent on beta cell heterogeneity and noise''. PLoS Computational Biology. [2016 Sep 28]; 12(9):e1005116. PMID: 27681078
  • Nikki L. Farnsworth, Rachelle L. Walter, Alireza Hemmati, Matthew J. Westacott, Richard K.P. Benninger. "Low level pro-inflammatory cytokines decrease connexin36 gap junction coupling in mouse and human islets through nitric oxide mediated protein kinase Cδ." The Journal of Biological Chemistry. [2015 Dec 14]; 291(7):3184-964. PMID: 26668311
  • Ricrard K.P. Benninger, Troy Hutchens, W. Steven Head, Michael J. McCaughey, Min Zhang, Sylvain J. Le Marchand, Leslie S. Satin, David W. Piston. "Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal calcium wave dynamics." Biophysical Journal. [2014 Dec 2]; 107(11):2723-33. PMID: 25468351
  • Eva Nozik-Grayck, Crystal Woods, Joann M. Taylor, Richard K.P. Benninger, Richard D. Johnson, Leah R. Villegas, Kurt R. Stenmark, David G. Harrison, Susan M. Majka, David Irwin, Kathryn N. Farrow. "Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension." American Journal of Physiology: Lung Cellular and Molecular Physiology. [2014 Dec 1]; 307(11):L868-76. PMID: 25326578​
  • Nikki L. Farnsworth, Alireza Hemmati, Marina Pozzoli, Thomas H. Hraha, Richard K.P. Benninger. “Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of langerhans." The Journal of Physiology. [2014 Oct 15]; 592(Pt 20):4431-46. PMID: 25172942
  • John M. Hartney, Timothy Stidham, David A. Goldstrohm, Rebecca E. Oberley-Deegan, Michael R. Weaver, Zuzana Valnickova-Hansen, Carsten Scavenius, Richard K.P. Benninger, Katelyn F. Leahy, Richard Johnson, Fabienne Gally, Beata Kosmider, Angela K. Zimmermann, Jan J. Enghild, Eva Nozik-Grayck, Russell P. Bowler. "A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution." Circulation: Cardiovascular Genetics. [2014 Oct]; 7(5):659-66. PMID: 25085920
  • Thomas H. Hraha, Matthrew J. Westacott, Marina Pozzoli, Aleena M. Notary, P. Mason McClatchey, Richard K.P. Benninger. "Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability." PLoS Computational Biology. [2014 Sep 4]; 10(9):e1003819. PMID: 25188228
  • Yan Hang, Tsunehiko Yamamoto, Richard K.P. Benninger, Marcela Brissova, Min Guo, Will Bush, David W. Piston, Alvin C. Powers, Mark Magnuson, Debbie C. Thurmond and Roland Stein. "The MafA transcription factor becomes essential to islet beta-cells soon after birth." Diabetes. [2014 Jun]; 63(6):1994-2005. PMID: 24520122
  • Linda M. Nguyen, Marina Pozzoli, Thomas H. Hraha, Richard K.P. Benninger. “Decreasing Cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes.” Diabetes. [2014 May]; 63(5):1685-97. PMID: 24458355
  • Thomas H. Hraha, Abigail B. Bernard, Linda M Nguyen, Kristi S. Anseth, Richard K.P. Benninger. “Dimensionality and size scaling of coordinated Ca2+ dynamics in pancreatic β-cell clusters.” Biophysical Journal. [2014 Jan 7]; 106(1):299-309. PMID: 24411262
  • W. Steven Head, Meredith L. Orseth, Craig S. Nunemaker, Leslie S. Satin, David W. Piston, Richard K.P. Benninger. “Connexin-36 gap junctions regulate in-vivo first and second phase insulin secretion dynamics and glucose tolerance in the conscious mouse.” Diabetes. [2012 Jul]; 61(7):1700-7. *Special Commentary. PMID: 22511206