Keith Neeves is a Professor of Bioengineering and Pediatrics at the University of Colorado Denver | Anschutz Medical Campus. He obtained his B.S. in chemical engineering from the University of Colorado, Boulder and a Ph.D. in chemical and biomolecular engineering at Cornell University. He was an NIH NRSA postdoctoral fellow at the University of Pennsylvania.
The research in the Neeves laboratory focuses on the mechanisms, diagnosis, and treatment of blood clotting disorders; including genetic bleeding disorders, thrombosis, and stroke. All of these disorders are perturbations of the physiologic process of forming a blood clot, or hemostasis.
We conduct fundamental studies of the flows and forces that regulate hemostasis using in vivo, in vitro, and in silico models of various types of blood vessels and vascular injuries. We use these models to make predictions and uncover new mechanisms related to the hemostatic system. Translational studies with these models for diagnostic applications are done in collaboration with clinicians at the Hemophilia and Thrombosis Center and Children’s Hospital Colorado.
We also are working on drug delivery strategies for treating bleeding and thrombotic disorders. We have developed magnetically powered microbots, about the size of a blood cell, that can assemble, target, and ablate blood clots. This technology is currently being evaluated for the treatment of small vessel strokes.
The Neeves Lab is located in the Department of Bioengineering at the University of Colorado, Denver Anschutz Medical Campus.